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Definition
Dermatitis herpetiformis is a chronic, extremely itchy rash consisting of bumps and blisters. Dermatitis herpetiformis is linked to sensitivity of the intestine to gluten in the diet (celiac sprue).
Alternative Names
Duhring's disease
Causes, incidence, and risk factors
Dermatitis herpetiformis usually begins in persons 20 and older, though children may sometimes be affected. It is seen in both men and women.
Though the cause of the rash is unknown, dermatitis herpetiformis is frequently associated with gluten (a protein found in cereals) sensitivity in the small bowel.
Symptoms
Dermatitis herpetiformis is usually extremely itchy. The bumps or blisters usually appear on the elbows, knees, back, and buttocks. In most cases, the rash is the same size and shape on both sides. Symptoms of dermatitis herpetiformis tend to get worse and get better.
Signs and tests
A skin biopsy and direct immunofluorescence test of the skin are performed in most cases. Your doctor may also recommend a biopsy of the intestines.
Treatment
Dapsone, an antibiotic, may help most patients.
A strict gluten-free diet will also be recommended to help control the disease. Sticking to this diet may remove the need for medications and prevent later complications.
Expectations (prognosis)
The disease may be well controlled with treatment.
Complications
Thyroid disease may be found in many patients with dermatitis herpetiformis. Patients are also more likely to develop certain cancers of the intestines.
Calling your health care provider
Call your physician if you develop an itchy rash or diarrhea.
Prevention
There is no known prevention of this disease. Avoidance of gluten-containing foods will help prevent complications in affected patients.
Reviewed By: Jonathan Kantor, M.D., Department of Dermatology, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
